Web29 feb. 2016 · PM184 is a marine -derive drug found in a sponge called Lithoplocamia lithistoides. This drug candidate is a microtubule inhibitor that targets a protein called tubulin in a novel way. It blocks cancer growth by impairing cell division of tumour cells through the inhibition of a crucial process called mitosis. WebOriginally isolated from the Madagascan marine sponge Lithoplocamia lithistoides, plocabulin is now obtained by total synthesis [3]. Plocabulin binds tubulin with high a nity, reducing its polymerization and depolymerization to a similar extent and thereby inhibiting microtubule dynamicity (Figure1) [4–6].
Frontiers Antitumoral Effect of Plocabulin in High Grade Serous ...
Web7 dec. 2024 · Plocabulin (PM184; Fig. 8) and its chloro-derivative (Fig. 8; PM-050489) were isolated by PharmaMar scientists from the sponge Lithoplocamia lithistoides, but due to the low levels in the extract, both … WebLithoplocamia is een geslacht van sponsdieren uit de klasse van de Demospongiae (gewone sponzen). 7 relaties: Lithoplocamia atlantica , Lithoplocamia dolichosclera , … small squishmallow turkey
Lithoplocamia lithistoides - Unionpedia
WebThese compounds were active against one or more drug-resistant pathogens such as methicillin-resistant Staphylococcus aureus, methicillin-resistant Staphylococcus epidermidis, vancomycin-resistant Enterococci, multidrug-resistant Mycobacterium tuberculosis, and amphotericin B-resistant Candida albicans. Web1 apr. 2014 · PM060184 belongs to a new family of tubulin-binding agents originally isolated from the marine sponge Lithoplocamia lithistoides. This compound is currently produced by total synthesis and is under evaluation in clinical … Webde Voogd, N.J.; Alvarez, B.; Boury-Esnault, N.; Carballo, J.L.; Cárdenas, P.; Díaz, M.-C.; Dohrmann, M.; Downey, R.; Hajdu, E.; Hooper, J.N.A.; Kelly, M.; Klautau ... highway 9 south carolina