WebAug 1, 2007 · Cisplatin/cysteinyl-glycine complexes were also found in the supernatant of GGT-transfected cisplatin-resistant HeLa cells ; this finding seems to indicate a poor membrane permeability of thiol/cisplatin complexes. It shouldalso be considered that cysteinyl-glycine reacts with cisplatin, approximately fivefold faster than GSH .
Hyperhomocysteinemia Exacerbates Cisplatin-induced Acute …
WebThis hypothesis was tested by pre-treating C57BL/6j mice with suramin prior to cisplatin. Our data indicates that suramin protects the kidney from injury by decreasing cisplatin-induced decreases in kidney function. Renal histology indicated that suramin significantly protected from cisplatin-induced AKI. Data indicate that suramin WebNov 1, 2001 · The cysteine-conjugates are taken up into the cell and converted to a reactive thiol by either cysteine-conjugate β-lyase or S-oxidase. ... cisplatin-cysteinyl-glycine-conjugates, and cisplatin-cysteine-conjugates are all more toxic to proximal tubule cells than cisplatin. 25 We have also shown that inhibition of cysteine-conjugate β-lyase by ... how many days till halloween 2020
Sodium selenite attenuated cisplatin-induced toxicity in rats: …
WebMar 13, 2024 · Aminopeptidase N (APN) converts cysteinyl-glycine-conjugates into cysteine-conjugates which are, after entering into the PTECs, further metabolized to highly reactive and nephrotoxic thiols by enzymic activity of cysteine-S-conjugate beta-lyase (CCBL) [22, 44]. Having in mind that, among all tissues, GGT has the highest activity in … WebCisplatin (24 mg/kg body weight) was given by a single intraperitoneal injection. Mice were killed at day 1 or day 3 after cisplatin administration, blood and kidney samples were harvested for further analysis. Renal ischemia-reperfusion was induced in mice as described previously [ 21, 22 ]. WebCysteinylglycine C5H10N2O3S - PubChem Apologies, we are having some trouble retrieving data from our servers... PUGVIEW FETCH ERROR: 403 Forbidden National … high street doynton bs30 5tf